Mouse CTR&RAMP1 UM-UC-3
CBP71649
询 价
索取protocol
产品描述
产品数据库
| I. Background | |
| 小鼠 Calcr（Calcitonin Receptor, CTR） 是 B 类 GPCR，单独高亲和结合降钙素（Calcitonin）激活 Gs/cAMP 通路，抑制破骨细胞骨吸收；Ramp1（Receptor Activity-Modifying Protein 1） 为单次跨膜辅助蛋白，与 Calcr 异源二聚化形成 AMY1（Amylin Receptor 1），使复合物对胰淀素（Amylin/IAPP）亲和力升高、降钙素亲和力降低，主要在下丘脑、孤束核及骨组织表达，参与摄食抑制、血糖调节和骨代谢。 | |
| II. Description | |
| Mouse CTR&RAMP1 UM-UC-3 细胞药靶模型很好的模拟了体内 CTR&RAMP1 的信号转导过程。 | |
| III. Introduction | |
| Host Cell: |
UM-UC-3 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: |
MEM+10%FBS+1% NEAA+ 1mM NaP+2μg/ml Puromycin+5μg/ml Blasticidin
|
| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Application(s): |
Functional assay for Mouse CTR&RAMP1 |
| Transducer: | Gs |
| IV. Representative Data | |
|
|
|
